Chemical Structure
Chemical Structure
PF-04979064 [1220699-06-8]
SYN-1194
CAS Number1220699-06-8
Product group Chemicals
Estimated Purity>95%
Molecular Weight446.5
Overview
- SupplierSYNkinase
- Product NamePF-04979064 [1220699-06-8]
- Delivery Days Customer10
- CAS Number1220699-06-8
- Estimated Purity>95%
- Molecular FormulaC24H26N6O3
- Molecular Weight446.5
- Scientific DescriptionChemical. CAS: 1220699-06-8. Formula: C24H26N6O3. MW: 446.5. PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC(50) of 9.1nM for the PI3K family when tested AKT phosphorylation in BT20 cells. In direct kinase assays, PF-04979064 has potent Ki values against PI3Kalpha (Ki= 0.13nM human, 0.299nM mouse) and PI3Kgamma (Ki=0.111nM), and PI3Kdelta (Ki=0.122nM). In contrast, Ki values for non-PI3K kinases such as mTOR were 10X higher at 1.42 nM. - PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC(50) of 9.1nM for the PI3K family when tested AKT phosphorylation in BT20 cells. In direct kinase assays, PF-04979064 has potent Ki values against PI3Kalpha (Ki= 0.13nM human, 0.299nM mouse) and PI3Kgamma (Ki=0.111nM), and PI3Kdelta (Ki=0.122nM). In contrast, Ki values for non-PI3K kinases such as mTOR were 10X higher at 1.42 nM.
- Storage Instruction2°C to 8°C
- UNSPSC51202000