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Chemical Structure
Chemical Structure
Chemical Structure

PF-04979064 [1220699-06-8]

Research Use Only
SYN-1194
SYNkinase
CAS Number1220699-06-8
Product group Chemicals
Estimated Purity>95%
Molecular Weight446.5
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Overview

  • Supplier
    SYNkinase
  • Product Name
    PF-04979064 [1220699-06-8]
  • Delivery Days Customer
    10
  • CAS Number
    1220699-06-8
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C24H26N6O3
  • Molecular Weight
    446.5
  • Scientific Description
    Chemical. CAS: 1220699-06-8. Formula: C24H26N6O3. MW: 446.5. PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC(50) of 9.1nM for the PI3K family when tested AKT phosphorylation in BT20 cells. In direct kinase assays, PF-04979064 has potent Ki values against PI3Kalpha (Ki= 0.13nM human, 0.299nM mouse) and PI3Kgamma (Ki=0.111nM), and PI3Kdelta (Ki=0.122nM). In contrast, Ki values for non-PI3K kinases such as mTOR were 10X higher at 1.42 nM. - PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC(50) of 9.1nM for the PI3K family when tested AKT phosphorylation in BT20 cells. In direct kinase assays, PF-04979064 has potent Ki values against PI3Kalpha (Ki= 0.13nM human, 0.299nM mouse) and PI3Kgamma (Ki=0.111nM), and PI3Kdelta (Ki=0.122nM). In contrast, Ki values for non-PI3K kinases such as mTOR were 10X higher at 1.42 nM.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    51202000