PF-3644022 [1276121-88-0]

MedChem Express

PF-3644022 [1276121-88-0]

10

1276121-88-0

Research Use Only

99.65

C21H18N4OS

374.46

PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFalpha production and has anti-inflammatory effect[1].

O=C1C2=C(NC[C@@H](C)N1)C3=C(C=CC4=NC(C5=CN=C(C)C=C5)=CC=C34)S2

-20°C,2°C to 8°C

12352200