PF-5006739 [1293395-67-1]

MedChem Express

PF-5006739 [1293395-67-1]

10

1293395-67-1

Research Use Only

99.94

C22H22FN7O

419.45

PF-5006739 is a potent and selective inhibitor of CK1delta/epsilon with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1delta/epsilon and high kinome selectivity. PF-5006739 attenuats opioid agent-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner[1]. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity[2].

NC1=NC=CC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCN(CC5=NOC=C5)CC4)=N1

2°C to 8°C

12352200