PF-5006739 [1293395-67-1]

TargetMol Chemicals

PF-5006739 [1293395-67-1]

14

1293395-67-1

Chemical

Research Use Only

PF-5006739

C22H22FN7O

419.45

PF-5006739 is an effective and selective inhibitor of CK1delta/epsilon (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1delta/epsilon and high kinome selectivity. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity. PF-5006739 decreases opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner.

3 years

Nc1nccc(n1)-c1c(ncn1C1CCN(Cc2ccon2)CC1)-c1ccc(F)cc1

-20°C

12352200