PF-6274484
HY-101450
CAS Number1035638-91-5
Product group Chemicals
Estimated Purity98.76
Molecular Weight372.78
Overview
- SupplierMedChem Express
- Product NamePF-6274484 [1035638-91-5]
- Delivery Days Customer10
- CAS Number1035638-91-5
- CertificationResearch Use Only
- Estimated Purity98.76
- Molecular FormulaC18H14ClFN4O2
- Molecular Weight372.78
- Scientific DescriptionPF-6274484 is a potent EGFR inhibitor with K i s of 0.14 nM and 0.18 nM for EGFR-L858R/T790M and WT EGFR, respectively. PF-6274484 inhibits EGFR-L858R/T790M autophosphorylation in H1975 tumor cells and EGFR WT in A549 tumor cells with IC 50 s of 6.6 and 5.8 nM, respectively [1] .
- SMILESC=CC(NC1=CC2=C(NC3=CC(Cl)=C(F)C=C3)N=CN=C2C=C1OC)=O
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200