PF-6274484 [1035638-91-5]

MedChem Express

PF-6274484 [1035638-91-5]

10

1035638-91-5

Research Use Only

98.76

C18H14ClFN4O2

372.78

PF-6274484 is a potent EGFR inhibitor with Kis of 0.14 nM and 0.18 nM for EGFR-L858R/T790M and WT EGFR, respectively. PF-6274484 inhibits EGFR-L858R/T790M autophosphorylation in H1975 tumor cells and EGFR WT in A549 tumor cells with IC50s of 6.6 and 5.8 nM, respectively[1].

C=CC(NC1=CC2=C(NC3=CC(Cl)=C(F)C=C3)N=CN=C2C=C1OC)=O

-20°C,2°C to 8°C

12352200