PF-6274484 [1035638-91-5]

TargetMol Chemicals

PF-6274484 [1035638-91-5]

4

1035638-91-5

Research Use Only

PF-6274484

99.12%

C18H14ClFN4O2

372.78

PF-6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.

3 years

COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C

-20°C

12352200