PG01

MedChem Express

PG01 [853138-65-5]

10

853138-65-5

Research Use Only

98.0

C28H29N3O2

439.55

PG01 is a potent CFTR Cl - channel potentiator. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K , G970R and G551D (CFTR mutants) with K d values of 0.22 microM, 0.45 microM and 1.94 microM, respectively. PG01 is also effective on deltaF508 ( K a of 0.3 microM). PG01 increases deltaF508-CFTR Cl - current after adding Forskolin [1] [2] .

O=C(N(C)C(C1=CC=CC=C1)C(NC2=CC=C(C(C)C)C=C2)=O)CC3=CNC4=C3C=CC=C4

-20°C

12352200