PHF21A Polyclonal Antibody

Reddot Biotech

PHF21A Polyclonal Antibody

5

Western Blot

Research Use Only

1 mg/ml

Unconjugated

PHF21A

PHD finger protein 21A

BHC80; BHC80a; BM-006; BRAF35/HDAC2 complex (80 kDa); BRAF35-HDAC complex protein BHC80; IDDBCS; NEDMS; PHD finger protein 21A

Rabbit

IgG

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. PHF21A (PHD finger protein 21A), also known as BRAF35-HDAC complex protein BHC80, is a 680 amino acid nuclear protein that contains one PHD-type zinc finger and one A.T hook DNA-binding domain, suggesting involvement in transcriptional regulation events. PHF21A is a component of the BHC complex, which is responsible for repressing transcription of neuron-specific genes in non-neuronal cells. The BHC complex acts as a chromatin modifier that deacetylates and demethylates specific sites on histones. PHF21A may act as a scaffold within the BHC complex. Predominantly expressed in brain, three isoforms of PHF21A exist as a result of alternative splicing events.

Human, Mouse, Rat

-20°C

12352203