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ProductsBack/Phomoxanthone A [359844-69-2]
Chemical Structure
Chemical Structure
Chemical Structure

Phomoxanthone A [359844-69-2]

Research Use Only
AG-CN2-0017
AdipoGen Life Sciences
CAS Number359844-69-2
DownloadMSDS
Product group Chemicals
Estimated Purity>97%
Molecular Weight750.7
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Phomoxanthone A [359844-69-2]
  • Delivery Days Customer
    10
  • CAS Number
    359844-69-2
  • Certification
    Research Use Only
  • Estimated Purity
    >97%
  • Molecular Formula
    C38H38O16
  • Molecular Weight
    750.7
  • Scientific Description
    Anticancer compound. Shows antimalarial and antitubercular activity. Cytotoxic against several cancer cell lines. Antibacterial against Gram-positive bacteria and antifungal. Activator of murine T lymphocytes, NK cells and macrophages. Mitochondrial toxin with a mode of action distinct from known electron transport chain (ETC) inhibitors, OXPHOS uncouplers and ionophores. Shows rapid inhibition of both ETC and DeltaPsim, the release of mitochondrial Ca2+ and fission of the inner but not the outer mitochondrial membrane independent from the mitochondrial fission and fusion regulators DRP1 and OPA1. - Chemical. CAS: 359844-69-2. Formula: C38H38O16. MW: 750.7. Isolated from fungus Phoma sp. Anticancer compound. Shows antimalarial and antitubercular activity. Cytotoxic against several cancer cell lines. Antibacterial against Gram-positive bacteria and antifungal. Activator of murine T lymphocytes, NK cells and macrophages.
  • SMILES
    C[C@@H]1CC(O)=C2C(=O)C3=C(O[C@]2(COC(C)=O)[C@@H]1OC(C)=O)C(=CC=C3O)C1=C2O[C@]3(COC(C)=O)[C@H](OC(C)=O)[C@H](C)CC(O)=C3C(=O)C2=C(O)C=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Phomoxanthones A and B, novel xanthone dimers from the endophytic fungus Phomopsis species: M. Isaka, et al.; J. Nat. Prod. 64, 1015 (2001)
  • X-ray Structure Determination, Absolute Configuration and Biological Activity of Phomoxanthone A: B. Elsasser, et al.; Eur. J. Org. Chem. 2005, 4563 (2005)
  • Anticancer compounds derived from fungal endophytes: their importance and future challenges: R.N. Kharwar, et al.; Nat. Prod. Rep. 28, 1208 (2011)
  • Pro-apoptotic and immunostimulatory tetrahydroxanthone dimers from the endophytic fungus Phomopsis Iongicolla: D. Rönsberg, et al.; J. Org. Chem. 78, 12409 (2013)