Phomoxanthone A

MedChem Express

Phomoxanthone A [359844-69-2]

5

359844-69-2

Research Use Only

C38H38O16

750.70

Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis . Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC 50 is 0.11 microg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 microg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC 50 is 0.99, 0.51 and 1.4 microg/mL, respectively [1] .

O=C1C2=C(O[C@@]3(COC(C)=O)[C@@H](OC(C)=O)[C@@H](C)CC(O)=C31)C(C4=CC=C(O)C5=C4O[C@@]6(COC(C)=O)[C@@H](OC(C)=O)[C@@H](C)CC(O)=C6C5=O)=CC=C2O

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