Phomoxanthone A [359844-69-2]

AdipoGen Life Sciences

Phomoxanthone A

10

359844-69-2

Research Use Only

>97%

C38H38O16

750.7

Anticancer compound. Shows antimalarial and antitubercular activity. Cytotoxic against several cancer cell lines. Antibacterial against Gram-positive bacteria and antifungal. Activator of murine T lymphocytes, NK cells and macrophages. Mitochondrial toxin with a mode of action distinct from known electron transport chain (ETC) inhibitors, OXPHOS uncouplers and ionophores. Shows rapid inhibition of both ETC and DeltaPsim, the release of mitochondrial Ca2+ and fission of the inner but not the outer mitochondrial membrane independent from the mitochondrial fission and fusion regulators DRP1 and OPA1. - Chemical. CAS: 359844-69-2. Formula: C38H38O16. MW: 750.7. Isolated from fungus Phoma sp. Anticancer compound. Shows antimalarial and antitubercular activity. Cytotoxic against several cancer cell lines. Antibacterial against Gram-positive bacteria and antifungal. Activator of murine T lymphocytes, NK cells and macrophages.

C[C@@H]1CC(O)=C2C(=O)C3=C(O[C@]2(COC(C)=O)[C@@H]1OC(C)=O)C(=CC=C3O)C1=C2O[C@]3(COC(C)=O)[C@H](OC(C)=O)[C@H](C)CC(O)=C3C(=O)C2=C(O)C=C1

-20°C,2°C to 8°C

12352200