Phospho-FBXL3 (Ser320) Antibody

Cusabio

Phospho-FBXL3 (Ser320) Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

FBXL3

F-box and leucine rich repeat protein 3

FBL3; FBL3A; F-box and leucine-rich repeat protein 3A; F-box protein Fbl3a; F-box/LRR-repeat protein 3; F-box/LRR-repeat protein 3A; FBXL3A; IDDSFAS

Rabbit

IgG

F-box/LRR-repeat protein 3

Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. 1)Busino L., Bassermann F., Maiolica A., Lee C., Nolan P.M., Godinho S.I., Draetta G.F., Pagano M. Science 316:900-904(2007) 2)Yoo S.H., Mohawk J.A., Siepka S.M., Shan Y., Huh S.K., Hong H.K., Kornblum I., Kumar V., Koike N., Xu M., Nussbaum J., Liu X., Chen Z., Chen Z.J., Green C.B., Takahashi J.S.Cell 152:1091-1105(2013)

Human, Mouse, Rat

-20°C or -80°C

12352203