Phospho-PRKACA (Thr197) Antibody

Cusabio

Phospho-PRKACA (Thr197) Antibody

20

ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

PRKACA

protein kinase cAMP-activated catalytic subunit alpha

CAFD1, PKACA, PPNAD4, cAMP-dependent protein kinase catalytic subunit alpha, PKA C-alpha, protein kinase A catalytic subunit, protein kinase, cAMP-dependent, alpha catalytic subunit, protein kinase, cAMP-dependent, catalytic, alpha

Rabbit

IgG

cAMP-dependent protein kinase catalytic subunit alpha

Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Ghislaine Garrel, Endocrinology, Jun 1997; 138: 2259. W Li, Learn. Mem., Jan 1996; 2: 320 - 333. Sharmin Schauble, J. Biol. Chem., May 2007; 282: 14952 - 14959. Yong G. Wang, J. Gen. Physiol., Jan 1998; 111: 113.

Human, Mouse, Rat

-20°C or -80°C

41116161