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Western blot analysis of extracts from K562 cells untreated(lane 1) or treated with serum(lane 2) using Rb(Phospho-Ser795) Antibody.
Western blot analysis of extracts from K562 cells untreated(lane 1) or treated with serum(lane 2) using Rb(Phospho-Ser795) Antibody.
Western blot analysis of extracts from K562 cells untreated(lane 1) or treated with serum(lane 2) using Rb(Phospho-Ser795) Antibody.

Phospho-RB1 (Ser795) Antibody

CSB-PA201739
Cusabio
ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetRB1
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Overview

  • Supplier
    Cusabio
  • Product Name
    Phospho-RB1 (Ser795) Antibody
  • Delivery Days Customer
    20
  • Applications
    ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID5925
  • Target name
    RB1
  • Target description
    RB transcriptional corepressor 1
  • Target synonyms
    exon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; OSRC; p105-Rb; p110-RB1; pp110; PPP1R130; pRb; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; RB; retinoblastoma 1; retinoblastoma suspectibility protein; retinoblastoma-associated protein
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP06400
  • Protein Name
    Retinoblastoma-associated protein
  • Scientific Description
    Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 Lys-20 trimethylation. Inhibits the intrinsic kinase activity of TAF1. In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1s activity. Fang Sun , Hanjiang Fu , Qin Liu, et al. (2008) Downregulation of CCND1 and CDK6 by miR-34a induces cell cyclearrest. FEBS Letters, 582:1564
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203