Rb antibody

Name: Rb antibody
SKU: GTX100545_G10
Availability: BackOrder

GTX100545

ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman

TargetRB1

Overview

Supplier
GeneTex
Product Name
Rb antibody
Delivery Days Customer
9
Application Supplier Note
ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1.47 mg/ml
Conjugate
Unconjugated
Gene ID5925
Target name
RB1
Target description
RB transcriptional corepressor 1
Target synonyms
OSRC, PPP1R130, RB, p105-Rb, p110-RB1, pRb, pp110, retinoblastoma-associated protein, prepro-retinoblastoma-associated protein, protein phosphatase 1, regulatory subunit 130, retinoblastoma 1, retinoblastoma suspectibility protein
Host
Rabbit
Isotype
IgG
Protein IDP06400
Protein Name
Retinoblastoma-associated protein
Scientific Description
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq]
Reactivity
Human
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Cheng TC, Sayseng JO, Tu SH, et al. Curcumin-induced antitumor effects on triple-negative breast cancer patient-derived xenograft tumor mice through inhibiting salt-induced kinase-3 protein. J Food Drug Anal. 2021,29(4):622-637. doi: 10.38212/2224-6614.3387
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Liang ML, Chen CH, Liu YR, et al. Abemaciclib, A Selective CDK4/6 Inhibitor, Restricts the Growth of Pediatric Ependymomas. Cancers (Basel). 2020,12(12). doi: 10.3390/cancers12123597
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Sikorski K, Mehta A, Inngjerdingen M, et al. A high-throughput pipeline for validation of antibodies. Nat Methods. 2018,15(11):909-912. doi: 10.1038/s41592-018-0179-8
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Chen YJ, Cheng YJ, Hung AC, et al. The synthetic flavonoid WYC02-9 inhibits cervical cancer cell migration/invasion and angiogenesis via MAPK14 signaling. Gynecol Oncol. 2013,131(3):734-43. doi: 10.1016/j.ygyno.2013.10.012
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