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Phospholamban antibody

Name: Phospholamban antibody
SKU: GTX109254_G10
Availability: BackOrder

GTX109254

ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetPLN

Overview

Supplier
GeneTex
Product Name
Phospholamban antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:1000-1:10000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1.63 mg/ml
Conjugate
Unconjugated
Gene ID5350
Target name
PLN
Target description
phospholamban
Target synonyms
CMD1P, CMH18, PLB, phospholamban, cardiac phospholamban
Host
Rabbit
Isotype
IgG
Protein IDP26678
Protein Name
Phospholamban
Scientific Description
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Shen L, Li C, Zhang H, et al. Downregulation of miR-146a Contributes to Cardiac Dysfunction Induced by the Tyrosine Kinase Inhibitor Sunitinib. Front Pharmacol. 2019,10:914. doi: 10.3389/fphar.2019.00914
Read this paper
Zhang Y, Jiao L, Sun L, et al. LncRNA ZFAS1 as a SERCA2a Inhibitor to Cause Intracellular Ca(2+) Overload and Contractile Dysfunction in a Mouse Model of Myocardial Infarction. Circ Res. 2018,122(10):1354-1368. doi: 10.1161/CIRCRESAHA.117.312117
Read this paper