Phospholamban (phospho Ser16) antibody
GTX132818
Overview
- SupplierGeneTex
- Product NamePhospholamban (phospho Ser16) antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.97 mg/ml
- ConjugateUnconjugated
- Gene ID5350
- Target namePLN
- Target descriptionphospholamban
- Target synonymscardiac phospholamban; CMD1P; CMH18; PLB
- HostRabbit
- IsotypeIgG
- Protein IDP26678
- Protein NameCardiac phospholamban
- Scientific DescriptionThe protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq]
- ReactivityMouse, Rabbit
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Beneficial Electrophysiological Effects of Rotigaptide Are Unable to Suppress Therapeutic Hypothermia-Provoked Ventricular Fibrillation in Failing Rabbit Hearts With Acute Ischemia-Reperfusion Injury. Lee HL et al., 2021, Front PhysiolRead more