PI-103 (Hydrochloride)

MedChem Express

PI-103 (Hydrochloride) [371935-79-4]

10

371935-79-4

Research Use Only

98.55

C19H17ClN4O3

384.82

PI-103 Hydrochloride is a dual PI3K and mTOR inhibitor with IC 50 s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110alpha , p110beta , p110delta , p110gamma , mTORC1 , and mTORC2 . PI-103 Hydrochloride also inhibits DNA-PK with an IC50 of 2 nM. PI-103 Hydrochloride induces autophagy [1] [2] [3] [4] .

OC1=CC(C2=NC3=C(OC4=C3C=CC=N4)C(N5CCOCC5)=N2)=CC=C1.[H]Cl

2°C to 8°C

12352200