IHC-P analysis of human ovary adenocarcinoma tissue using GTX83886 PIM2 antibody [10A12]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50
![IHC-P analysis of kidney tissue using GTX83886 PIM2 antibody [10A12]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50](https://www.genetex.com/upload/website/prouct_img/normal/GTX83886/GTX83886_1971_IHC-P_w_23061420_472.webp "IHC-P analysis of kidney tissue using GTX83886 PIM2 antibody [10A12]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50")
![IHC-P analysis of pancreas tissue using GTX83886 PIM2 antibody [10A12]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50](https://www.genetex.com/upload/website/prouct_img/normal/GTX83886/GTX83886_1972_IHC-P_w_23061420_624.webp "IHC-P analysis of pancreas tissue using GTX83886 PIM2 antibody [10A12]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50")
![FACS analysis of HEK293T cells transfected with either PIM2 plasmid(Red) or empty vector control plasmid(Blue) using GTX83886 PIM2 antibody [10A12].](https://www.genetex.com/upload/website/prouct_img/normal/GTX83886/GTX83886_216_FACS_w_23061420_704.webp "FACS analysis of HEK293T cells transfected with either PIM2 plasmid(Red) or empty vector control plasmid(Blue) using GTX83886 PIM2 antibody [10A12].")
![WB analysis of various cell lines using GTX83886 PIM2 antibody [10A12]. Loading : 35 ug per lane](https://www.genetex.com/upload/website/prouct_img/normal/GTX83886/GTX83886_3469_WB_w_23061420_871.webp "WB analysis of various cell lines using GTX83886 PIM2 antibody [10A12]. Loading : 35 ug per lane")
![WB analysis of HEK293T cells transfected with PIM2 plasmid (Right) or empty vector (Left) for 48 hrs using GTX83886 PIM2 antibody [10A12]. Loading : 5 ug per lane](https://www.genetex.com/upload/website/prouct_img/normal/GTX83886/GTX83886_3970_WB_w_23061420_402.webp "WB analysis of HEK293T cells transfected with PIM2 plasmid (Right) or empty vector (Left) for 48 hrs using GTX83886 PIM2 antibody [10A12]. Loading : 5 ug per lane")
IHC-P analysis of human ovary adenocarcinoma tissue using GTX83886 PIM2 antibody [10A12]. Antigen retrieval : Heat-induced epitope retrieval by 10mM citrate buffer, pH6.0, 100oC for 10min. Dilution : 1:50
PIM2 antibody [10A12]
GTX83886
ApplicationsFlow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetPIM2
Overview
- SupplierGeneTex
- Product NamePIM2 antibody [10A12]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:1000. IHC-P: 1:50. FACS: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID10A12
- Concentration0.84 mg/ml
- ConjugateUnconjugated
- Gene ID11040
- Target namePIM2
- Target descriptionPim-2 proto-oncogene, serine/threonine kinase
- Target synonymsserine/threonine-protein kinase pim-2, pim-2 oncogene, pim-2h, proto-oncogene Pim-2 (serine threonine kinase)
- HostMouse
- IsotypeIgG2a
- Protein IDQ9P1W9
- Protein NameSerine/threonine-protein kinase pim-2
- Scientific DescriptionPromotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappaB kinase/NF-kappaB cascade - this process requires phosphorylation of MAP3K8/COT. Prevents apoptosis induced by growth factor withdrawal via inhibition of caspase-3 activation, and via phosphorylation of pro-apoptotic proteins. Inhibits BAD-induced cell death via phosphorylation of BAD. PIM2-mediated cell survival is glucose-dependent but independent of several AKT regulators such as PI3K, HSP-90 and TOR, indicating that PIM2 and PI3K/AKT/TOR function via distinct pathways. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
Datasheet
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