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ProductsBack/PIN1 inhibitor API-1 [680622-70-2]

PIN1 inhibitor API-1 [680622-70-2]

Research Use Only
HY-116716
MedChem Express
CAS Number680622-70-2
DownloadMSDS
Product group Chemicals
Estimated Purity98.54
Molecular Weight366.30
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Overview

  • Supplier
    MedChem Express
  • Product Name
    PIN1 inhibitor API-1 [680622-70-2]
  • Delivery Days Customer
    10
  • CAS Number
    680622-70-2
  • Certification
    Research Use Only
  • Estimated Purity
    98.54
  • Molecular Formula
    C15H13F3N6O2
  • Molecular Weight
    366.30
  • Scientific Description
    PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC50 of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development[1].
  • SMILES
    O=C(NCC1=CC=C(COC2=C3NC=NC3=NC(N)=N2)C=C1)C(F)(F)F
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200