PIN1 inhibitor API-1 [680622-70-2]
T16538
CAS Number680622-70-2
Product group Chemicals
Estimated Purity98.48%
Molecular Weight366.3
Overview
- SupplierTargetMol Chemicals
- Product NamePIN1 inhibitor API-1 [680622-70-2]
- Delivery Days Customer10
- CAS Number680622-70-2
- CertificationResearch Use Only
- Chemical NamePIN1 inhibitor API-1
- Estimated Purity98.48%
- Molecular FormulaC15H13F3N6O2
- Molecular Weight366.3
- Scientific DescriptionPIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM) that retains the active conformation of pXPO5, restoring its ability to transport pre-miRNAs from the nucleus to the cytoplasm, thereby up-regulating anticancer miRNA biogenesis to suppress hepatocellular carcinoma development both in vitro and in vivo. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase domain, effectively inhibiting Pin1 cis-trans isomerizing activity.
- Shelf life instruction3 years
- SMILESNc1nc(OCc2ccc(CNC(=O)C(F)(F)F)cc2)c2[nH]cnc2n1
- Storage Instruction-20°C
- UNSPSC51202000
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