More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/PIN1 inhibitor API-1
CgoaEWY7KyCEYLVmAAAAAOzMCNk023.png
CgoaEWY7KyCEYLVmAAAAAOzMCNk023.png
CgoaEWY7KyCEYLVmAAAAAOzMCNk023.png

PIN1 inhibitor API-1

Research Use Only
T16538
TargetMol Chemicals
CAS Number680622-70-2
Product group Chemicals
Molecular Weight366.3
Price on request
Packing Size
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    PIN1 inhibitor API-1
  • Delivery Days Customer
    10
  • CAS Number
    680622-70-2
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    PIN1 inhibitor API-1
  • Molecular Formula
    C15H13F3N6O2
  • Molecular Weight
    366.3
  • Scientific Description
    PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase domain and effectively inhibits Pin1 cis-trans isomerizing activity.
  • Shelf life instruction
    3 years
  • SMILES
    O(CC1=CC=C(CNC(C(F)(F)F)=O)C=C1)C2=C3C(N=CN3)=NC(N)=N2
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Pu W, et al. Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellularcarcinoma development. Hepatology. 2018 Aug;68(2):547-560.
    Read more