PLK1-IN-9

MedChem Express

PLK1-IN-9 [893772-67-3]

5

893772-67-3

Research Use Only

C12H7F3N4O2

296.20

PLK1-IN-9 (Compound M2) is an inhibitor for polo-like kinase 1 (PLK1), that inhibits PLK proteins modified with peptides 1010pT, cdc25c and PBIP, with IC50s of 1.6, 0.8 and 1.4 microM, respectively. PLK1-IN-9 inhibits proliferations of cancer cells HeLa, HL60, SNU387/499, HepG2, exhibits cytotoxicity and induces apoptosis. PLK1-IN-9 inhibits tumor growth in HepG2 xenograft mouse model[1].

CN1C2=C(N=C3C1=NC(NC3=O)=O)C=C(C(F)(F)F)C=C2

12352200