PLK1-IN-9
ORB2564718
CAS Number893772-67-3
Product group Chemicals
Estimated Purity98.00%
Molecular Weight296.2
Overview
- SupplierBiorbyt
- Product NamePLK1-IN-9 [893772-67-3]
- Delivery Days Customer10
- CAS Number893772-67-3
- CertificationResearch Use Only
- Estimated Purity98.00%
- Molecular FormulaC12H7F3N4O2
- Molecular Weight296.2
- Scientific DescriptionPLK1-IN-9 (Compound M2), a polo-like kinase 1 (PLK1) inhibitor, targets the PLK proteins modified with peptides 1010pT, cdc25c, and PBIP, exhibiting IC50 values of 1.6, 0.8, and 1.4 microM, respectively. This compound effectively inhibits the proliferation of various cancer cell lines including HeLa, HL60, SNU387/499, and HepG2, demonstrating cytotoxic effects and inducing apoptosis. Additionally, PLK1-IN-9 has been shown to suppress tumor growth in a HepG2 xenograft mouse model.
- SMILESO=C1N=C2C(=NC=3C=C(C=CC3N2C)C(F)(F)F)C(=O)N1
- Storage Instruction-20°C
- UNSPSC12352200
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Product group Chemicals
PLK1-IN-9 [893772-67-3]T87975
CAS Number893772-67-3
Molecular Weight296.2
- SizePrice
