PMX-53

MedChem Express

PMX-53 [219639-75-5]

9

Research Use Only

99.98

PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC 50 of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2 -mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects [1] [2] [3] [4] [5] [6] .

-20°C,-80°C

12352200