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Polycystin 2 antibody

GTX113802
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Zebra Fish
TargetPKD2
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Overview

  • Supplier
    GeneTex
  • Product Name
    Polycystin 2 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5311
  • Target name
    PKD2
  • Target description
    polycystin 2, transient receptor potential cation channel
  • Target synonyms
    APKD2; autosomal dominant polycystic kidney disease type II protein; PC2; Pc-2; PKD4; polycystic kidney disease 2 (autosomal dominant); polycystin-2; transient receptor potential cation channel subfamily P member 2; TRPP2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ13563
  • Protein Name
    Polycystin-2
  • Scientific Description
    This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. The encoded protein may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1 to produce cation-permeable currents. Mutations in this gene have been associated with autosomal dominant polycystic kidney disease. [provided by RefSeq]
  • Reactivity
    Human, Zebra Fish
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Zebrafish Model as a Screen to Prevent Cyst Inflation in Autosomal Dominant Polycystic Kidney Disease. Oliveira I et al., 2021 Aug 20, Int J Mol Sci
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  • The zebrafish Kupffers vesicle as a model system for the molecular mechanisms by which the lack of Polycystin-2 leads to stimulation of CFTR. Roxo-Rosa M et al., 2015 Oct 2, Biol Open
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