Ponatinib-d8 [1562993-37-6]

MedChem Express

Ponatinib-d8 [1562993-37-6]

10

1562993-37-6

Research Use Only

99.91

C29H19D8F3N6O

540.61

Ponatinib-d8 is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRalpha, VEGFR2, FGFR1, and Src, respectively.

O=C(NC1=CC=C(CN2C([2H])([2H])C([2H])([2H])N(C)C([2H])([2H])C2([2H])[2H])C(C(F)(F)F)=C1)C3=CC=C(C)C(C#CC4=CN=C5C=CC=NN54)=C3

-20°C,2°C to 8°C

12352200