Poseltinib [1353552-97-2]

TargetMol Chemicals

Poseltinib [1353552-97-2]

14

1353552-97-2

Chemical

Research Use Only

Poseltinib

C26H26N6O3

470.52

Poseltinib is an orally active, selective, and irreversible Brutons tyrosine kinase (BTK) inhibitor, exhibiting a half-maximal inhibitory concentration (IC 50) of 1.95 nM. It demonstrates 0.3, 2.3, and 2.4-fold greater selectivity for BTK over BMX, TEC, and TXK, respectively. This compound covalently binds to BTKs active site at the cysteine 481 residue, effectively inhibiting signaling pathways mediated by the B cell receptor (BCR), Fc receptor (FcR), and Toll-like receptor (TLR).

3 years

CN1CCN(CC1)c1ccc(Nc2nc(Oc3cccc(NC(=O)C=C)c3)c3occc3n2)cc1

-20°C

12352200