PPM1A antibody [p6c7]

GeneTex

PPM1A antibody [p6c7]

9

ELISA: Assay-dependent dilution WB: 1:250- 1:1000 ICC/IF: 1:100 Optimal dilutions/concentrations should be determined by the researcher.

ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry

Research Use Only

Monoclonal

p6c7

1 mg/ml

Unconjugated

PPM1A

protein phosphatase, Mg2+/Mn2+ dependent 1A

PP2CA; PP2Calpha; PP2C-ALPHA; protein phosphatase 1A

Mouse

IgG2b

Protein phosphatase 1A

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

-20°C or -80°C,2°C to 8°C

12352203