PPP1R15B antibody

GeneTex

PPP1R15B antibody

9

WB: 0.1-0.5microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

500 ug/ml

Unconjugated

PPP1R15B

protein phosphatase 1 regulatory subunit 15B

CREP; MSSGM2; protein phosphatase 1 regulatory subunit 15B; protein phosphatase 1, regulatory (inhibitor) subunit 15B

Rabbit

IgG

Protein phosphatase 1 regulatory subunit 15B

This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. [provided by RefSeq, Feb 2016]

Human

-20°C or -80°C,2°C to 8°C

12352203