PPP4C antibody
GTX114659
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse
TargetPPP4C
Overview
- SupplierGeneTex
- Product NamePPP4C antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.29 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID5531
- Target namePPP4C
- Target descriptionprotein phosphatase 4 catalytic subunit
- Target synonymsepididymis secretory sperm binding protein; PP4; PP4C; PPH3; PPP4; PPX; PP-X; protein phosphatase 4 (formerly X), catalytic subunit; protein phosphatase X, catalytic subunit; serine/threonine-protein phosphatase 4 catalytic subunit
- HostRabbit
- IsotypeIgG
- Protein IDP60510
- Protein NameSerine/threonine-protein phosphatase 4 catalytic subunit
- Scientific DescriptionProtein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase.
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203