PPP4C antibody [N1], N-term

GeneTex

PPP4C antibody [N1], N-term

9

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

0.45 mg/ml

Unconjugated

PPP4C

protein phosphatase 4 catalytic subunit

epididymis secretory sperm binding protein; PP4; PP4C; PPH3; PPP4; PPX; PP-X; protein phosphatase 4 (formerly X), catalytic subunit; protein phosphatase X, catalytic subunit; serine/threonine-protein phosphatase 4 catalytic subunit

Rabbit

IgG

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase.

Human

2°C to 8°C,-20°C or -80°C

12352203