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PR-619 [2645-32-1]

PR-619 [2645-32-1]

Research Use Only
T1862
TargetMol Chemicals
CAS Number2645-32-1
DownloadMSDS
Product group Chemicals
Estimated Purity99.83%
Molecular Weight223.28
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    PR-619 [2645-32-1]
  • Delivery Days Customer
    9
  • CAS Number
    2645-32-1
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    PR-619
  • Estimated Purity
    99.83%
  • Molecular Formula
    C7H5N5S2
  • Molecular Weight
    223.28
  • Scientific Description
    PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor that inhibits USP2/4/5/7/8 (EC50=7.2/3.93/8.61/6.86/4.9 microM). PR-619 induces endoplasmic reticulum stress and activates autophagy.
  • Shelf life instruction
    3 years
  • SMILES
    Nc1nc(N)c(SC#N)cc1SC#N
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • The Deubiquitinating Enzyme Inhibitor PR-619 Enhances the Cytotoxicity of Cisplatin via the Suppression of Anti-Apoptotic Bcl-2 Protein: In Vitro and In Vivo Study. Kuo KL et al., 2019 Oct 17, Cells
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