Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA13669A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA13669A0Rb at dilution of 1:100
PRKRA Antibody
CSB-PA13669A0RB
ApplicationsImmunoFluorescence, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetPRKRA
Overview
- SupplierCusabio
- Product NamePRKRA Antibody
- Delivery Days Customer20
- ApplicationsImmunoFluorescence, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID8575
- Target namePRKRA
- Target descriptionprotein activator of interferon induced protein kinase EIF2AK2
- Target synonymsDYT16; HSD14; interferon-inducible double-stranded RNA-dependent protein kinase activator A; PACT; PKR-associated protein X; PKR-associating protein X; protein activator of the interferon-induced protein kinase; protein kinase, interferon-inducible double-stranded RNA-dependent activator; RAX
- HostRabbit
- IsotypeIgG
- Protein IDO75569
- Protein NameInterferon-inducible double-stranded RNA-dependent protein kinase activator A
- Scientific DescriptionActivates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at \\\Lys-386\\\ at \\\Ser-392\\\ respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203