ProductsBack/Prohibitin antibody

Prohibitin antibody

Name: Prohibitin antibody
SKU: GTX101105_G10
Availability: BackOrder

GTX101105

ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetPHB

Overview

Supplier
GeneTex
Product Name
Prohibitin antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.34 mg/ml
Conjugate
Unconjugated
Gene ID5245
Target name
PHB
Target description
prohibitin
Target synonyms
epididymis luminal protein 215; epididymis secretory sperm binding protein Li 54e; HEL-215; HEL-S-54e; PHB1; prohibitin
Host
Rabbit
Isotype
IgG
Protein IDP35232
Protein Name
Prohibitin
Scientific Description
Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3 untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3 untranslated region may function as a trans-acting regulatory RNA. [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Accumulation of cholesterol suppresses oxidative phosphorylation and altered responses to inflammatory stimuli of macrophages. Chiu YC et al., 2021 Dec, Biochem Biophys Rep
Read more
A novel c-Kit/phospho-prohibitin axis enhances ovarian cancer stemness and chemoresistance via Notch3-PBX1 and beta-catenin-ABCG2 signaling. Fang CH et al., 2020 Mar 13, J Biomed Sci
Read more
Contribution of Extracellular Matrix and Signal Mechanotransduction to Epithelial Cell Damage in Inflammatory Bowel Disease Patients: A Proteomic Study. Moriggi M et al., 2017 Dec, Proteomics
Read more
Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours. Yurugi H et al., 2017 Aug 17, Oncogene
Read more
5-Methoxytryptophan-dependent protection of cardiomyocytes from heart ischemia reperfusion injury. Chou HC et al., 2014 Feb 1, Arch Biochem Biophys
Read more