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Prohibitin antibody

Name: Prohibitin antibody
SKU: GTX101105_G10
Availability: BackOrder

GTX101105

ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetPHB1

Overview

Supplier
GeneTex
Product Name
Prohibitin antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.34 mg/ml
Conjugate
Unconjugated
Gene ID5245
Target name
PHB1
Target description
prohibitin 1
Target synonyms
BAP32, HEL-215, HEL-S-54e, PHB, prohibitin 1, epididymis luminal protein 215, epididymis secretory sperm binding protein Li 54e, prohibitin
Host
Rabbit
Isotype
IgG
Protein IDP35232
Protein Name
Prohibitin 1
Scientific Description
Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3 untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3 untranslated region may function as a trans-acting regulatory RNA. [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Chiu YC, Chu PW, Lin HC, et al. Accumulation of cholesterol suppresses oxidative phosphorylation and altered responses to inflammatory stimuli of macrophages. Biochem Biophys Rep. 2021,28:101166. doi: 10.1016/j.bbrep.2021.101166
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Fang CH, Lin YT, Liang CM, et al. A novel c-Kit/phospho-prohibitin axis enhances ovarian cancer stemness and chemoresistance via Notch3-PBX1 and β-catenin-ABCG2 signaling. J Biomed Sci. 2020,27(1):42. doi: 10.1186/s12929-020-00638-x
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Moriggi M, Pastorelli L, Torretta E, et al. Contribution of Extracellular Matrix and Signal Mechanotransduction to Epithelial Cell Damage in Inflammatory Bowel Disease Patients: A Proteomic Study. Proteomics. 2017,17(23-24). doi: 10.1002/pmic.201700164
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Yurugi H, Marini F, Weber C, et al. Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours. Oncogene. 2017,36(33):4778-4789. doi: 10.1038/onc.2017.93
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Chou HC, Chan HL. 5-Methoxytryptophan-dependent protection of cardiomyocytes from heart ischemia reperfusion injury. Arch Biochem Biophys. 2014,543:15-22. doi: 10.1016/j.abb.2013.12.014
Read this paper