PROTAC Mcl1 degrader-1

MedChem Express

PROTAC Mcl1 degrader-1 [2163793-38-0]

10

2163793-38-0

Research Use Only

98.13

C45H45BrN6O8S

909.84

PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC50 of 0.78 microM. PROTAC Mcl1 degrader-1 inhibits Bcl-2 with an IC50 of 0.54 microM[1].

O=C(C1=CC=CC(NCCCCCCNC(CCCCC(NCCN2C(C3=C4C(C2=O)=CC=C(C4=CC=C3)SC5=CC=C(C=C5)Br)=O)=O)=O)=C1C6=O)N6C7CCC(NC7=O)=O

-20°C

12352200