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PROTAC Mcl1 degrader-1

Research Use Only
T11975
TargetMol Chemicals
CAS Number2163793-38-0
Product group Chemicals
Molecular Weight909.84
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    PROTAC Mcl1 degrader-1
  • Delivery Days Customer
    999
  • CAS Number
    2163793-38-0
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    PROTAC Mcl1 degrader-1
  • Molecular Formula
    C45H45BrN6O8S
  • Molecular Weight
    909.84
  • Scientific Description
    PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with uM-range affinity. PROTAC Mcl1 degrader-1, a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 uM.
  • Shelf life instruction
    3 years
  • SMILES
    O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCCCCCNC(=O)CCCCC(=O)NCCN4C(=O)C5=CC=CC=6C(SC7=CC=C(Br)C=C7)=CC=C(C4=O)C56)C3C2=O)CC1
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.
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