PS210 [1221962-86-2]

MedChem Express

PS210 [1221962-86-2]

10

1221962-86-2

Research Use Only

99.79

C19H15F3O5

380.31

PS210 is a potent and selective PDK1 activator with a Kd of 3 microM and targets the PIF-binding pocket of PDK1. PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt or GSK3. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K[1][2].

O=C(C(C(O)=O)C(CC(C1=CC=C(C=C1)C(F)(F)F)=O)C2=CC=CC=C2)O

-20°C

12352200