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ProductsBack/PSD95 antibody

PSD95 antibody

GTX133091
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetDlg4
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Overview

  • Supplier
    GeneTex
  • Product Name
    PSD95 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IHC-Fr: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.24 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID13385
  • Target name
    Dlg4
  • Target description
    discs large MAGUK scaffold protein 4
  • Target synonyms
    discs large homolog 4; discs, large homolog 4; disks large homolog 4; Dlgh; Dlgh4; postsynaptic density protein 95; PSD; PSD-; PSD95; PSD-95; PSD-95 alpha 2b; PSD-95 beta; SA; SAP90; SAP-90; SAP90A; synapse-associated protein 90
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ62108
  • Protein Name
    Disks large homolog 4
  • Scientific Description
    Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ACCN3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Peptide immunization against the C-terminal of alpha-synuclein reduces locomotor activity in mice overexpressing alpha-synuclein.
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  • Dysfunctional synaptic pruning by microglia correlates with cognitive impairment in sleep-deprived mice: Involvement of CX3CR1 signaling.
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  • Low-Intensity Focused Ultrasound Stimulation Ameliorates Working Memory Dysfunctions in Vascular Dementia Rats via Improving Neuronal Environment. Wang F et al., 2022, Front Aging Neurosci
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  • Maternal Cigarette Smoke Exposure Exaggerates the Behavioral Defects and Neuronal Loss Caused by Hypoxic-Ischemic Brain Injury in Female Offspring. Huang T et al., 2022, Front Cell Neurosci
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  • MEF2C ameliorates learning, memory, and molecular pathological changes in Alzheimers disease in vivo and in vitro.
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  • In vitro modulation of Schwann cell behavior by VEGF and PDGF in an inflammatory environment. Basu S et al., 2022 Jan 13, Sci Rep
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  • Blood-Brain Barrier Disruption Increases Amyloid-Related Pathology in TgSwDI Mice. Abdallah IM et al., 2021 Jan 27, Int J Mol Sci
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  • Rapid differentiation of human dental pulp stem cells to neuron-like cells by high K+ stimulation. Kogo Y et al., 2020, Biophys Physicobiol
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  • Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice. Son Y et al., 2020 Aug 3, Int J Mol Sci
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  • Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype. Hou B et al., 2020 May 15, Cell Death Dis
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