More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/PSEN1 Antibody
Western Blot Positive WB detected in: MCF-7 whole cell lysate All lanes: PSEN1 antibody at 3ug/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 53, 43, 22, 47, 49 kDa Observed band size: 53 kDa
Western Blot Positive WB detected in: MCF-7 whole cell lysate All lanes: PSEN1 antibody at 3ug/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 53, 43, 22, 47, 49 kDa Observed band size: 53 kDa
Western Blot Positive WB detected in: MCF-7 whole cell lysate All lanes: PSEN1 antibody at 3ug/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 53, 43, 22, 47, 49 kDa Observed band size: 53 kDa

PSEN1 Antibody

CSB-PA018846EA01HU
Cusabio
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetPSEN1
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    Cusabio
  • Product Name
    PSEN1 Antibody
  • Delivery Days Customer
    20
  • Applications
    Western Blot, ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID5663
  • Target name
    PSEN1
  • Target description
    presenilin 1
  • Target synonyms
    ACNINV3, AD3, CMD1U, FAD, PS-1, PS1, PSNL1, S182, presenilin-1, familial Alzheimer Disease
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP49768
  • Protein Name
    Presenilin-1
  • Scientific Description
    Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    41116161

FAQ

Go to our frequently asked questions

Related products

Product group Antibodies
Assay Genie
Presenilin 1 AntibodyCAB2187
TargetPSEN1
  • SizePrice
Product group Antibodies
References
GeneTex
Presenilin 1 antibody [C1C2], InternalGTX116016
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
TargetPSEN1
  • SizePrice
Product group Antibodies
MedChem Express
Presenilin 1 Antibody (YA1722, Rabbit)HY-P81977
TargetPSEN1
  • SizePrice
Product group Antibodies
Biosynth
Presenilin 1 antibody20-PG71
  • SizePrice
Product group Antibodies
RayBiotech
Anti-PSEN1 Antibody144-65495
ApplicationsImmunoFluorescence, Western Blot, ImmunoHistoChemistry
TargetPSEN1
  • SizePrice
Figure 1. Western blot analysis of Presenilin 1/PS-1/PSEN1 using anti-Presenilin 1/PS-1/PSEN1 antibody (A00138-3). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample under reducing conditions. Lane 1: human RT4 whole cell lysates, Lane 2: human MCF-7 whole cell lysates, Lane 3: human Caco-2 whole cell lysates, Lane 4: rat brain tissue lysates, Lane 5: mouse brain tissue lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. Blocked the membrane with 5% non-fat milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-Presenilin 1/PS-1/PSEN1 antigen affinity purified polyclonal antibody (Catalog # A00138-3) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for Presenilin 1/PS-1/PSEN1 at approximately 53 kDa. The expected band size for Presenilin 1/PS-1/PSEN1 is at 53 kDa.
Product group Antibodies
Boster Bio
Anti-Presenilin 1/PS-1/PSEN1 Antibody Picoband(r)A00138-3-CARRIER-FREE
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry
TargetPSEN1
  • SizePrice
Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity with a granular pattern in neuronal cells.
Product group Antibodies
Atlas Antibodies
Anti-PSEN1 AntibodyHPA030760
ApplicationsImmunoHistoChemistry
ReactivityHuman
TargetPSEN1
  • SizePrice
Product group Antibodies
Biomatik
PSEN1 Polyclonal AntibodyCAC14546
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
TargetPSEN1
  • SizePrice
K562 Cell lysates probed with presenilin 1 Polyclonal Antibody, unconjugated (bs-0024R) at 1:300 overnight at 4°C followed by a conjugated secondary antibody at 1:10000 for 60 minutes at 37°C.
Product group Antibodies
References
Bioss
Presenilin 1 Polyclonal AntibodyBS-0024R
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
TargetPSEN1
  • SizePrice
Product group Antibodies
LifeSpan BioSciences
PSEN1 / Presenilin 1 AntibodyLS-C331969
ApplicationsWestern Blot, ImmunoHistoChemistry
TargetPSEN1
  • SizePrice