Bio-Connect
Western blot analysis of extracts of U-87MG cells using PSEN1 Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts of U-87MG cells using PSEN1 Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts of U-87MG cells using PSEN1 Polyclonal Antibody at dilution of 1:1000.

PSEN1 Polyclonal Antibody

E-AB-60669
Elabscience
Product group Antibodies
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Elabscience
  • Product Name
    PSEN1 Polyclonal Antibody
  • Delivery Days Customer
    12
  • Certification
    Research Use Only
  • Scientific Description
    Alzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
  • UNSPSC
    12352203