Western blot analysis of extracts of U-87MG cells using PSEN1 Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts of U-87MG cells using PSEN1 Polyclonal Antibody at dilution of 1:1000.
PSEN1 Polyclonal Antibody
E-AB-60669
Product group Antibodies
Overview
- SupplierElabscience
- Product NamePSEN1 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionAlzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
- UNSPSC12352203