Bio-Connect

PUF60 antibody [GT917]

GTX629887
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetPUF60
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Overview

  • Supplier
    GeneTex
  • Product Name
    PUF60 antibody [GT917]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    GT917
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID22827
  • Target name
    PUF60
  • Target description
    poly(U) binding splicing factor 60
  • Target synonyms
    FBP interacting repressor; FIR; FUSE-binding protein-interacting repressor; poly(U) binding splicing factor 60KDa; poly(U)-binding-splicing factor PUF60; pyrimidine tract binding splicing factor; Ro ribonucleoprotein-binding protein 1; RoBPI; Siah binding protein 1; SIAHBP1; VRJS
  • Host
    Mouse
  • Isotype
    IgG2b
  • Protein IDQ9UHX1
  • Protein Name
    Poly(U)-binding-splicing factor PUF60
  • Scientific Description
    The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • The SYNGAP1 3UTR Variant in ALS Patients Causes Aberrant SYNGAP1 Splicing and Dendritic Spine Loss by Recruiting HNRNPK. Yokoi S et al., 2022 Nov 23, J Neurosci
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