Pyridone 6

MedChem Express

Pyridone 6 [457081-03-7]

10

457081-03-7

Research Use Only

98.13

C18H16FN3O

309.34

Pyridone 6 is a pan-JAK inhibitor, which potently inhibits the JAK kinase family, with IC 50 s of 1 nM for JAK2 and TYK2 , 5 nM for JAK3 , and 15 nM for JAK1 , while displaying significantly weaker affinities (130 nM to >10 mM) for other protein tyrosine kinases.

FC1=CC2=C(C(NC=C3)=O)C3=C(N=C(C(C)(C)C)N4)C4=C2C=C1

-20°C,2°C to 8°C

12352200