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Pyruvate Kinase (liver/RBC) antibody

Research Use Only
GTX111536
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Rat
TargetPKLR
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Overview

  • Supplier
    GeneTex
  • Product Name
    Pyruvate Kinase (liver/RBC) antibody
  • Delivery Days Customer
    9
  • Antibody Specificity
    This antibody is raised against the R-Type isoform. Based on a BLAST result, it may also react with the L-Type isoform.
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID5313
  • Target name
    PKLR
  • Target description
    pyruvate kinase L/R
  • Target synonyms
    PK1; PKL; PKRL; pyruvate kinase 1; pyruvate kinase isozyme R/L; pyruvate kinase isozymes L/R; pyruvate kinase isozymes R/L; pyruvate kinase PKLR; pyruvate kinase type L; pyruvate kinase, liver and blood cell; pyruvate kinase, liver and RBC; red cell/liver pyruvate kinase; RPK; R-type/L-type pyruvate kinase
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP30613
  • Protein Name
    Pyruvate kinase PKLR
  • Scientific Description
    The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
  • Reactivity
    Human, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Dietary supplementation with myo-inositol reduces hepatic triglyceride accumulation and expression of both fructolytic and lipogenic genes in rats fed a high-fructose diet. Shimada M et al., 2017 Nov, Nutr Res
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