PZ09

Biorbyt

PZ09 [1132609-87-0]

10

1132609-87-0

Research Use Only

C25H25N7

423.524

PZ09 (PKC-zeta inhibitor 9, PKC-aeta inhibitor PZ9) is a potent, isoform selective PKC-zeta (PKC-aeta) inhibitor with IC50 of 5.18 nM, displays excellent selectivity (>200-fold) over other PKC isoforms with exception of PKC-i (10-fold). PZ09 also shows high selectivity for CDK-2 (>200-fold), as well as a broader range of other kinases (<50% inhibition at 10 uM). PZ09 is a small-molecule inhibitor, the first tool to successfully interrogate aPKC signaling in cells.

CN1CCN(C2C3NC(C4C5C(=CC(C6C=CC(N)=CC=6)=CC=5)NN=4)=NC=3C=CC=2)CC1

12352200