R-8507 [338773-13-0]

TargetMol Chemicals

R-8507 [338773-13-0]

44

338773-13-0

Chemical

Research Use Only

R-8507

C16H8ClF3N4

348.71

R-8507 is a small molecule antagonist of the TNF-alpha type 1 receptor (TNF-alphaRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-alpha and IL-1beta with EC50 values of 2.45 and 3.79 microM, respectively, in an ELISA using A549 lung epithelial cells. It also disrupts the interaction of the TNF-alphaRI with receptor interacting protein 1 (RIP1) and TNF-alphaR-associated death domain protein (TRADD), preventing internalization of the receptor complex.

3 years

FC(F)(F)C1=NC2=CC=CC=C2N2C(=NN=C12)C1=CC=C(Cl)C=C1

-20°C

12352200