TNF-alpha-IN-19 [338773-13-0]

MedChem Express

TNF-alpha-IN-19 [338773-13-0]

5

338773-13-0

Research Use Only

C16H8ClF3N4

348.71

TNF-alpha-IN-19 is an inhibitor of TNFalpha that can block the interaction between TNFalphaRI, TRADD, and RIP1, the EC50 values for TNFalpha, IL-1beta, and IL-1beta/TNFalpha are 2.451, 3.792 and 1.54 microM, respectively. TNF-alpha-IN-19 only inhibits the degradation of IkappaBalpha when cells are stimulated by TNFalpha and not by IL-1beta[1].

ClC1=CC=C(C2=NN=C3N2C4=C(N=C3C(F)(F)F)C=CC=C4)C=C1

12352200