(R)-(-)-Gossypol acetic acid [866541-93-7]

MedChem Express

(R)-(-)-Gossypol acetic acid [866541-93-7]

10

866541-93-7

Research Use Only

98.93

C32H34O10

578.61

(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260+/-30 nM, 170+/-10 nM, and 480+/-40 nM, respectively.

OC1=C2C(C=O)=C(O)C(O)=C(C(C)C)C2=CC(C)=[C@]1[C@]3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O.CC(O)=O

-20°C

12352200