(R)-Roscovitine [186692-46-6]

AdipoGen Life Sciences

(R)-Roscovitine

10

186692-46-6

Research Use Only

>98%

C19H26N6O

354.5

Chemical. CAS: 186692-46-6. Formula: C19H26N6O. MW: 354.5. Potent and selective inhibitor of CDKs. More potent than olomoucine. Inhibits CDK1/cyclin B kinase (IC50 = 450 nM), CDK2 (IC50 = 700 nM) and CDK5/p35 (IC50 = 160 nM). Inhibits M phase promoting factor (MPF) kinase activity. Arrests human fibroblasts in G1 phase. Antitumor compound. Activates the mitogen-activated protein kinase pathway. Targets both the p53 and NF-kappaB pathways[10]. Has effects on calcium channel gating. Prevents DNA damage-induced cyclin A1 upregulation. Apoptosis inducer. As CYC202 in phase I clinical trials. Reviews. - Potent and selective inhibitor of CDKs [1, 2, 4, 16]. More potent than olomoucine [3]. Inhibits CDK1/cyclin B kinase (IC50 = 450 nM) [2], CDK2 (IC50 = 700 nM) [4] and CDK5/p35 (IC50 = 160 nM) [4,5]. Inhibits M phase promoting factor (MPF) kinase activity [2]. Arrests human fibroblasts in G1 phase [6]. Antitumor compound [8]. Activates the mitogen-activated protein kinase pathway [9]. Targets both the p53 and NF-kappaB pathways[10]. Has effects on calcium channel gating [12, 17, 18]. Prevents DNA damage-induced cyclin A1 upregulation [13]. Apoptosis inducer [11, 15, 20]. As CYC202 in phase I clinical trials [14]. Reviews [3, 7, 19].

CC[C@H](CO)NC1=NC2=C(N=CN2C(C)C)C(NCC2=CC=CC=C2)=N1

-20°C,2°C to 8°C

12352200