R406

MedChem Express

R406 [841290-81-1]

10

841290-81-1

Research Use Only

96.70

C28H29FN6O8S

628.63

R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a K i of 30 nM, potently inhibits Syk kinase activity in vitro with an IC 50 of 41 nM, measured at an ATP concentration corresponding to its K m value. R406 reduces immune complex-mediated inflammation [1] . R406 also inhibits Lyn (IC 50 =63 nM) and Lck (IC 50 =37 nM) [2] .

COC1=CC(NC2=NC(NC3=NC(N4)=C(C=C3)OC(C)(C)C4=O)=C(C=N2)F)=CC(OC)=C1OC.OS(C5=CC=CC=C5)(=O)=O

2°C to 8°C

12352200