Bio-Connect

Rabbit anti Human SIAH1, E3 Ubiquitin Ligase

Research Use Only
X1864P
Nordic-MUbio
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
TargetSIAH1
Price on request
50 ug
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Nordic-MUbio
  • Product Name
    Rabbit anti Human SIAH1, E3 Ubiquitin Ligase
  • Delivery Days Customer
    7
  • Application Supplier Note
    Antibody can be used for Western blotting (1-5 microg/ml). Optimal concentration should be evaluated by serial dilutions.
  • Applications
    Western Blot
  • Applications Supplier
    Western Blotting;Western Blotting
  • Category Supplier
    Primary antibodies
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Gene ID6477
  • Target name
    SIAH1
  • Target description
    siah E3 ubiquitin protein ligase 1
  • Target synonyms
    BURHAS; E3 ubiquitin-protein ligase SIAH1; RING-type E3 ubiquitin transferase SIAH1; seven in absentia homolog 1; SIAH1A; siah-1a
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ8IUQ4
  • Protein Name
    E3 ubiquitin-protein ligase SIAH1
  • Scientific Description
    SIAH1 (seven in absentia homolog 1), E3 Ubiquitin Ligase
  • Shelf life instruction
    See expiration date on vial
  • Reactivity
    Human
  • Reactivity Supplier
    Human
  • Reactivity Supplier Note
    Synthetic peptide derived from the human SIAH-1 protein.
  • Storage Instruction
    -80°C
  • UNSPSC
    12352203

References

  • 1: Hu G., et al.; Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.; Genes Dev. 11:2701-2714(1997). 2: Matsuzawa S., et al.; p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.; EMBO J. 17:2736-2747(1998). 3: Hu G., Fearon E.R.; Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins.; Mol. Cell. Biol. 19:724-732(1999). 4: Germani A., et al.; SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis.; Oncogene 19:5997-6006(2000). 5: Tanikawa J., et al.; p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3.; J. Biol. Chem. 275:15578-15585(2000). 6: Matsuzawa S., Reed J.C.; Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.; Mol. Cell 7:915-926(2001). 7: Liu J., et al. Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein.; Mol. Cell 7:927-936(2001). 8: Tiedt R., et al.; The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1.; EMBO J. 20:4143-4152(2001). 9: Boehm J., et al.; Regulation of BOB.1/OBF.1 stability by SIAH.; EMBO J. 20:4153-4162(2001). 10: Susini L., et al.; Siah-1 binds and regulates the function of Numb. Proc. Natl. Acad. Sci. U.S.A. 98:15067-15072(2001).